Abstract:Predicting how a cell will change its transcriptional state under a developmental signal or a genetic perturbation is the computational core of in-silico biology and the AI Virtual Cell program. Existing approaches either fit static control-to-treated maps that discard time, or solve multi-step ODE / Schrödinger-bridge problems on each dataset independently. We introduce Chreode, a one-step cell world model that predicts action-conditioned cell-state transitions through a structured residual transition operator. It shifts distributional evolution from inference time to training time, enabling single-pass generation while preserving a Waddington-inspired decomposition into downhill landscape flow, rotational in-tangent dynamics, and stochastic spread. The model is pretrained with a shared scVI encoder and a DiT-based dynamics backbone on a 2.4M-cell mouse embryonic atlas spanning 7 datasets. As a fine-tuning initialization, Chreode improves per-target Sinkhorn distance on Weinreb hematopoiesis and Veres islet differentiation over matched scratch models, PI-SDE, and PRESCIENT. As a transferable gene-state embedding for GEARS, the pretrained dynamics representation reduces shared-vocabulary DE20 mean squared error on Norman Perturb-seq from 0.2121 to 0.1858, a 12.4% relative improvement, without changing the GEARS training procedure. We interpret this transfer to perturbation prediction as evidence that pretrained developmental-trajectory dynamics encode differentiation primitives transferable to CRISPR-induced state shifts, since both involve cell-state transitions in a shared latent geometry. The pretrained backbone additionally produces zero-shot clonal fate scores on Weinreb that are competitive with strong dynamic-OT baselines.
Abstract:The rapid emergence of Large Language Models (LLMs) has catalyzed Agentic artificial intelligence (AI), autonomous systems integrating perception, reasoning, and action into closed-loop pipelines for continuous adaptation. While unlocking transformative applications in mobile edge computing, autonomous systems, and next-generation wireless networks, this paradigm creates fundamental energy challenges through iterative inference and persistent data exchange. Unlike traditional AI where bottlenecks are computational Floating Point Operations (FLOPs), Agentic AI faces compounding computational and communication energy costs. In this survey, we propose an energy accounting framework identifying computational and communication costs across the Perception-Reasoning-Action cycle. We establish a unified taxonomy spanning model simplification, computation control, input and attention optimization, and hardware-aware inference. We explore cross-layer co-design strategies jointly optimizing model parameters, wireless transmissions, and edge resources. Finally, we identify open challenges of federated green learning, carbon-aware agency, 6th generation mobile communication (6G)-native Agentic AI, and self-sustaining systems, providing a roadmap for scalable autonomous intelligence.
Abstract:Prior studies on mixed near-field and far-field communications have focused exclusively on single-cell scenarios, where both near-field and far-field users are served by the same base station (BS), leading to intra-cell mixed-field interference. In this paper, we consider a more general and practical multi-cell mixed-field scenario consisting of multiple cells, each serving multiple users, thus resulting in more complex inter-cell mixed-field interference. To address this new challenge, we propose leveraging rotatable antenna (RA) technology to enhance multi-cell mixed-field communication performance by exploiting the additional spatial degree-of-freedom introduced by RA rotation to mitigate interference in an efficient way. Specifically, we study an RA-enabled multi-cell mixed-field communication system in which each BS is equipped with an RA array to serve its associated users. We formulate a network-wide sum-rate maximization problem that jointly optimizes the transmit beamforming and the rotation angles of the RA arrays, subject to per-BS power constraints and admissible array rotation limits. To gain useful insights into the role of RAs in multi-cell mixed-field communications, we first analyze a special case with a single user per cell. For this case, we obtain a closed-form expression for the rotation-aware inter-cell mixed-field interference using the Fresnel integrals and analytically show that RA rotation can effectively mitigate such interference, thereby substantially improving system performance. For the general case with multiple users per cell, we develop an efficient double-layer algorithm: the inner layer optimizes the transmit beamforming at each BS via semidefinite relaxation and successive convex approximation; while the outer layer determines the rotation angles of the RA arrays using particle swarm optimization.
Abstract:Accurate parameter selection is fundamental to gyrokinetic plasma simulations, yet current practices rely heavily on manual literature reviews, leading to inefficiencies and inconsistencies. We introduce Plasma GraphRAG, a novel framework that integrates Graph Retrieval-Augmented Generation (GraphRAG) with large language models (LLMs) for automated, physics-grounded parameter range identification. By constructing a domain-specific knowledge graph from curated plasma literature and enabling structured retrieval over graph-anchored entities and relations, Plasma GraphRAG enables LLMs to generate accurate, context-aware recommendations. Extensive evaluations across five metrics, comprehensiveness, diversity, grounding, hallucination, and empowerment, demonstrate that Plasma GraphRAG outperforms vanilla RAG by over $10\%$ in overall quality and reduces hallucination rates by up to $25\%$. {Beyond enhancing simulation reliability, Plasma GraphRAG offers a methodology for accelerating scientific discovery across complex, data-rich domains.
Abstract:The International Telecommunication Union (ITU) identifies "Artificial Intelligence (AI) and Communication" as one of six key usage scenarios for 6G. Agentic AI, characterized by its ca-pabilities in multi-modal environmental sensing, complex task coordination, and continuous self-optimization, is anticipated to drive the evolution toward agent-based communication net-works. Semantic communication (SemCom), in turn, has emerged as a transformative paradigm that offers task-oriented efficiency, enhanced reliability in complex environments, and dynamic adaptation in resource allocation. However, comprehensive reviews that trace their technologi-cal evolution in the contexts of agent communications remain scarce. Addressing this gap, this paper systematically explores the role of semantics in agent communication networks. We first propose a novel architecture for semantic-based agent communication networks, structured into three layers, four entities, and four stages. Three wireless agent network layers define the logical structure and organization of entity interactions: the intention extraction and understanding layer, the semantic encoding and processing layer, and the distributed autonomy and collabora-tion layer. Across these layers, four AI agent entities, namely embodied agents, communication agents, network agents, and application agents, coexist and perform distinct tasks. Furthermore, four operational stages of semantic-enhanced agentic AI systems, namely perception, memory, reasoning, and action, form a cognitive cycle guiding agent behavior. Based on the proposed architecture, we provide a comprehensive review of the state-of-the-art on how semantics en-hance agent communication networks. Finally, we identify key challenges and present potential solutions to offer directional guidance for future research in this emerging field.
Abstract:Multi-uncrewed aerial vehicle (UAV) cooperative perception has emerged as a promising paradigm for diverse low-altitude economy applications, where complementary multi-view observations are leveraged to enhance perception performance via wireless communications. However, the massive visual data generated by multiple UAVs poses significant challenges in terms of communication latency and resource efficiency. To address these challenges, this paper proposes a communication-efficient cooperative perception framework, termed Base-Station-Helped UAV (BHU), which reduces communication overhead while enhancing perception performance. Specifically, we employ a Top-K selection mechanism to identify the most informative pixels from UAV-captured RGB images, enabling sparsified visual transmission with reduced data volume and latency. The sparsified images are transmitted to a ground server via multi-user MIMO (MU-MIMO), where a Swin-large-based MaskDINO encoder extracts bird's-eye-view (BEV) features and performs cooperative feature fusion for ground vehicle perception. Furthermore, we develop a diffusion model-based deep reinforcement learning (DRL) algorithm to jointly select cooperative UAVs, sparsification ratios, and precoding matrices, achieving a balance between communication efficiency and perception utility. Simulation results on the Air-Co-Pred dataset demonstrate that, compared with traditional CNN-based BEV fusion baselines, the proposed BHU framework improves perception performance by over 5% while reducing communication overhead by 85%, providing an effective solution for multi-UAV cooperative perception under resource-constrained wireless environments.
Abstract:Recently, visual localization has become an important supplement to improve localization reliability, and cross-view approaches can greatly enhance coverage and adaptability. Meanwhile, future 6G will enable a globally covered mobile communication system, with a space-air-ground integrated network (SAGIN) serving as key supporting architecture. Inspired by this, we explore an integration of cross-view localization (CVL) with 6G SAGIN, thereby enhancing its performance in latency, energy consumption, and privacy protection. First, we provide a comprehensive review of CVL and SAGIN, highlighting their capabilities, integration opportunities, and potential applications. Benefiting from the fast and extensive image collection and transmission capabilities of the 6G SAGIN architecture, CVL achieves higher localization accuracy and faster processing speed. Then, we propose a split-inference framework for implementing CVL, which fully leverages the distributed communication and computing resources of the 6G SAGIN architecture. Subsequently, we conduct joint optimization of communication, computation, and confidentiality within the proposed split-inference framework, aiming to provide a paradigm and a direction for making CVL efficient. Experimental results validate the effectiveness of the proposed framework and provide solutions to the optimization problem. Finally, we discuss potential research directions for 6G SAGIN-enabled CVL.
Abstract:Backdoor attacks against pre-trained models (PTMs) have traditionally operated under an ``immediacy assumption,'' where malicious behavior manifests instantly upon trigger occurrence. This work revisits and challenges this paradigm by introducing \textit{\textbf{Delayed Backdoor Attacks (DBA)}}, a new class of threats in which activation is temporally decoupled from trigger exposure. We propose that this \textbf{temporal dimension} is the key to unlocking a previously infeasible class of attacks: those that use common, everyday words as triggers. To examine the feasibility of this paradigm, we design and implement a proof-of-concept prototype, termed \underline{D}elayed Backdoor Attacks Based on \underline{N}onlinear \underline{D}ecay (DND). DND embeds a lightweight, stateful logic module that postpones activation until a configurable threshold is reached, producing a distinct latency phase followed by a controlled outbreak. We derive a formal model to characterize this latency behavior and propose a dual-metric evaluation framework (ASR and ASR$_{delay}$) to empirically measure the delay effect. Extensive experiments on four (natural language processing)NLP benchmarks validate the core capabilities of DND: it remains dormant for a controllable duration, sustains high clean accuracy ($\ge$94\%), and achieves near-perfect post-activation attack success rates ($\approx$99\%, The average of other methods is below 95\%.). Moreover, DND exhibits resilience against several state-of-the-art defenses. This study provides the first empirical evidence that the temporal dimension constitutes a viable yet unprotected attack surface in PTMs, underscoring the need for next-generation, stateful, and time-aware defense mechanisms.
Abstract:Satellite-terrestrial communications are severely constrained by high path loss, limited spectrum resources, and time-varying channel conditions, rendering conventional bit-level transmission schemes inefficient and fragile, particularly in low signal-to-noise ratio (SNR) regimes. Semantic communication has emerged as a promising paradigm to address these challenges by prioritizing task-relevant information over exact bit recovery. In this paper, we propose a semantic forwarding-based semantic communication (SFSC) framework optimized for satellite-terrestrial networks. Specifically, we develop a vector-quantized joint semantic coding and modulation scheme, in which the semantic encoder and semantic codebook are jointly optimized to shape the constellation symbol distribution, improving channel adaptability and semantic compression efficiency. To mitigate noise accumulation and reduce on-board computational burden, we introduce a satellite semantic forwarding mechanism, enabling relay satellites to forward signals directly at the semantic level without full decoding and re-encoding. Furthermore, we design a channel-aware semantic reconstruction scheme based on feature-wise linear modulation (FiLM) to fuse the received SNR with semantic features, enhancing robustness under dynamic channel conditions. To support multi-user access, we further propose a codebook split-enhanced model division multiple access (CS-MDMA) method to improve spectral efficiency. Simulation results show that the proposed SFSC framework achieves a peak signal-to-noise ratio (PSNR) gain of approximately 7.9 dB over existing benchmarks in the low-SNR regime, demonstrating its effectiveness for robust and spectrum-efficient semantic transmission in satellite-terrestrial networks.
Abstract:Agentic artificial intelligence (AI) presents a promising pathway toward realizing autonomous and self-improving wireless network services. However, resource-constrained, widely distributed, and data-heterogeneous nature of wireless networks poses significant challenges to existing agentic AI that relies on centralized architectures, leading to high communication overhead, privacy risks, and non-independent and identically distributed (non-IID) data. Federated learning (FL) has the potential to improve the overall loop of agentic AI through collaborative local learning and parameter sharing without exchanging raw data. This paper proposes new federated agentic AI approaches for wireless networks. We first summarize fundamentals of agentic AI and mainstream FL types. Then, we illustrate how each FL type can strengthen a specific component of agentic AI's loop. Moreover, we conduct a case study on using FRL to improve the performance of agentic AI's action decision in low-altitude wireless networks (LAWNs). Finally, we provide a conclusion and discuss future research directions.